A friend sent you this.

Choose one answer

1. AReduced NAT2 enzyme activity leading to slower drug inactivation and higher steady-state plasma levels
2. BEnhanced first-pass hepatic extraction by oxidative enzymes, reducing oral bioavailability
3. CReduced plasma protein binding increasing the free fraction of drug available
4. DIncreased renal clearance of the parent drug via enhanced tubular secretion, lowering plasma concentration
5. EInduction of CYP450 enzymes causing faster oxidative drug elimination overall