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Choose one answer

1. AIt permanently increases the drug's volume of distribution, allowing all future maintenance doses to be given at a lower strength
2. BIt saturates first-pass hepatic metabolism so that subsequent doses are absorbed more completely
3. CIt prevents the formation of toxic metabolites that would otherwise accumulate at maintenance doses
4. DIt achieves therapeutic plasma concentration rapidly without needing to wait the usual 4 to 5 half-lives for accumulation
5. EIt converts the drug's kinetics from zero-order to first-order, allowing predictable accumulation