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1. AKetamine undergoes no hepatic metabolism whereas diazepam is renally cleared unchanged
2. BDiazepam produces dissociative anaesthesia whereas ketamine produces sedation only
3. CKetamine blocks an excitatory glutamate channel whereas diazepam enhances an inhibitory chloride channel
4. DBoth drugs act at the same single receptor subtype but with opposite, mutually exclusive binding affinities for the orthosteric site
5. EKetamine increases presynaptic GABA release whereas diazepam blocks neuronal glutamate reuptake transporters at the synapse