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1. ABenzodiazepines increase chloride channel opening frequency; barbiturates increase opening duration
2. BBenzodiazepines directly open the chloride channel without needing GABA present, unlike barbiturates
3. CBenzodiazepines block chloride channels, whereas barbiturates open potassium channels instead
4. DBenzodiazepines act mainly on glutamate NMDA receptors rather than on the GABA-A receptor complex
5. EBenzodiazepines reduce GABA synthesis in the presynaptic terminal, unlike barbiturates