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1. AClozapine lowers seizure threshold in a dose-dependent manner, with risk rising substantially at higher doses
2. BClozapine raises seizure threshold across its dose range, so this seizure is unrelated to his current medication
3. CClozapine's seizure risk stays constant regardless of daily dose once a therapeutic plasma level is reached
4. DClozapine causes seizures mainly through agranulocytosis-related fever rather than any direct effect on cortical excitability
5. EClozapine's seizure risk depends mainly on plasma sodium concentration rather than on the prescribed daily dose