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1. ASildenafil blocks serotonin reuptake within penile tissue, directly reversing the pharmacological cause of the dysfunction
2. BSildenafil increases dopamine release within the hypothalamus, which is believed to override the effect of sertraline
3. CSildenafil augments the nitric oxide-cyclic GMP pathway, offsetting the serotonergic contribution to dysfunction
4. DSildenafil antagonises serotonin 5-HT2A receptors, which is thought to be the main cause of sertraline-related dysfunction
5. ESildenafil reduces circulating sertraline levels, lowering serotonergic drive and thereby restoring normal erectile function