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1. AWeight-independent peripheral insulin resistance combined with weight-related effects on glucose handling
2. BDirect destruction of pancreatic beta cells via autoimmune mechanisms
3. CIncreased hepatic glycogen synthesis reducing circulating glucose initially before rebound hyperglycaemia
4. DSelective destruction of hypothalamic satiety centres causing only weight-driven hyperglycaemia
5. EAccelerated renal clearance of insulin leading to relative insulin deficiency